Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease
Identifieur interne : 002362 ( Main/Exploration ); précédent : 002361; suivant : 002363Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease
Auteurs : Bruno Fimm [Allemagne] ; Ines A. Heber [Allemagne] ; Volker A. Coenen [Allemagne] ; Christoph Fromm [Allemagne] ; Johannes Noth [Allemagne] ; Martin Kronenbuerger [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Attention, Attention (drug effects), Attention (physiology), Basal ganglion, Cognition, Combined Modality Therapy, Deep Brain Stimulation, Deep brain stimulation, Female, Frontal Lobe (drug effects), Frontal Lobe (physiopathology), Humans, Male, Mental Processes (drug effects), Mental Processes (physiology), Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Nervous system diseases, Neuropsychological Tests, Parietal, Parietal Lobe (drug effects), Parietal Lobe (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Random Allocation, Severity of Illness Index, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, attention, basal ganglia, cognition, fronto‐parietal network.
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug effects : Attention, Frontal Lobe, Mental Processes, Motor Activity, Parietal Lobe, Psychomotor Performance, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- physiology : Attention, Mental Processes, Motor Activity, Psychomotor Performance.
- physiopathology : Frontal Lobe, Parietal Lobe, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Combined Modality Therapy, Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Random Allocation, Severity of Illness Index.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22580
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1613">1613</biblScope><biblScope unit="page" to="1620">1620</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C5B48B5E21926C8B81620CAB6CC17DDF49DCD3E7</idno><idno type="DOI">10.1002/mds.22580</idno><idno type="ArticleID">MDS22580</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Attention</term><term>Attention (drug effects)</term><term>Attention (physiology)</term><term>Basal ganglion</term><term>Cognition</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Deep brain stimulation</term><term>Female</term><term>Frontal Lobe (drug effects)</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Male</term><term>Mental Processes (drug effects)</term><term>Mental Processes (physiology)</term><term>Middle Aged</term><term>Motor Activity (drug effects)</term><term>Motor Activity (physiology)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Parietal</term><term>Parietal Lobe (drug effects)</term><term>Parietal Lobe (physiopathology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Random Allocation</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic nucleus</term><term>attention</term><term>basal ganglia</term><term>cognition</term><term>fronto‐parietal network</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Attention</term><term>Frontal Lobe</term><term>Mental Processes</term><term>Motor Activity</term><term>Parietal Lobe</term><term>Psychomotor Performance</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Mental Processes</term><term>Motor Activity</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term><term>Parietal Lobe</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Random Allocation</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Attention</term><term>Cognition</term><term>Maladie de Parkinson</term><term>Noyau gris central</term><term>Noyau sousthalamique</term><term>Pariétal</term><term>Pathologie du système nerveux</term><term>Stimulation cérébrale profonde</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short‐term memory, learning, delayed verbal memory recall, and stimulus‐response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto‐parietal network of alertness. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Fimm, Bruno" sort="Fimm, Bruno" uniqKey="Fimm B" first="Bruno" last="Fimm">Bruno Fimm</name></region><name sortKey="Coenen, Volker A" sort="Coenen, Volker A" uniqKey="Coenen V" first="Volker A." last="Coenen">Volker A. Coenen</name><name sortKey="Fromm, Christoph" sort="Fromm, Christoph" uniqKey="Fromm C" first="Christoph" last="Fromm">Christoph Fromm</name><name sortKey="Heber, Ines A" sort="Heber, Ines A" uniqKey="Heber I" first="Ines A." last="Heber">Ines A. Heber</name><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name><name sortKey="Noth, Johannes" sort="Noth, Johannes" uniqKey="Noth J" first="Johannes" last="Noth">Johannes Noth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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